Vitamin B12 cream

I came across a very interesting story: Twenty years ago Karsten Klingelhöller, then a medical student in Germany, developed a cream containing mainly vitamin B12 and avocado oil to help his girlfriend with psoriasis. This cream turned out to be very effective not only in the treatment of psoriasis but also for eczema. Since then Mr.  Klingelhöller tried unsuccessfully to bring this cream onto the market, even though there has been a small clinical study demonstrating its effectiveness [1,2].  In 2009 the German television station WDR produced a documentary about the story of this cream with the title “Heilung unerwünscht” (“Healing not wanted”). This documentary claims that the reason, why this cream is not available to buy, is that many of the large pharmaceutical companies produce much more expensive products (e.g. cortisone containing creams, elidel, etc) which give them bigger bucks than a cheap cream of similar effectiveness but without the side effects.

The cream did come onto the marked shortly after this documentary aired and can now be bought under the name Mavena B12 (its first name was Regividerm) (It is not clear if the documentary was a smart PR move, or if the production finally started because of the documentary. Klaus Martens, the journalist who made this documentary and wrote a book about this case, lost his job at the television station shortly after. update: I just found out that Klaus Martens did no loose his job. He was only temporarily suspended). However, the cream is not approved as a medicine, but instead is sold as a medical product (this means there have not been done all clinical trails necessary to prove its safety and effectiveness, but more has been done than for cosmetic products).

The recipe of the cream is widely published online, e.g. on Esowatch, reflecting the original idea of mixing vitamin B12 with avocado oil, water and an emulsifier. The reasons why this cream might indeed be effective is that vitamin B12 binds and neutralizes nitrogen monoxide, which plays a role in acute inflammations.  However, this also means that vitamin B12 does not treat the cause of the inflammation but rather might prevent whatever aggravates the inflammation and itchiness. So this cream is certainly not a cure but might help with the itchiness.

There are two main criticisms about this cream: First, the documentary seems very much like a smart PR move to market the cream. The film presents the story in the light of David against Goliath without critically questioning the cream itself. Some of the doctors and scientists interviewed for this film retracted some of the things they said after the film aired. The second critique, which I think is the more serious one, addresses the clinical studies [1,2]. Not only is the number of subjects very small, but both studies mention the support of Regeneratio Pharma AG, Wuppertal, Germany in the acknowledgements. Regeneratio Pharma AG is the company that owns the patent to the cream, and one might wonder how truly independent this studies are.

So, is this again an empty promises? Do we again stand before a product that is supposed to miraculously help against eczema? Is there again someone just making money, or not so much money, on the expense of the very large number of desperate eczema sufferers? I am desperate. I just called my pharmacy and ordered the cream. 100g of hope for 28.95 Euros.


[1] Stücker M, Memmel U, Hoffmann M, Hartung J, Altmeyer P: Vitamin B12 Cream Containing Avocado Oil in the Therapy of Plaque Psoriasis. Dermatology 2001;203:141-147

[2] M. Stücker et al.: Topical vitamin B-a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial, The British journal of dermatology, 2004 May; Volume 150, Issue 5, S.977-983.

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5 Responses to Vitamin B12 cream

  1. Nar says:

    Thanks for creating this blog. You are such a great mom. I kind of which my mom was able to do this for me. Nevertheless, I’ve been trying to find relief from my eczema. I’ve had this problem one and off for the past 28 years. It recently has become much more severe. I was wondering how the B12 cream was going? Did you find it helpful?

    • Caroline says:

      Dear Nar, thanks for your comment. We are using the B12 cream and like it. It creams well and is not irritating. We use it mainly on J.’s head, face and neck, sometimes on the hands. J. had one very bad patch on the head and we had the impression that the cream helped. But I cannot say that the cream cures all eczema. One disadvantage of the cream is the color (it is bright pink) – but when applied thin one can barely notice. This cream is good – but it is not the ultimate remedy. But maybe it is worth a try. All the best to you!

  2. clo says:

    hi i was wondering if there was any way of ordering this cream. i am from new zealand and have heard this cream is great and would love to try it for my psoriasis. thank you.

    • Caroline says:

      Hi Cloe, one way for you to get the cream might be to find a local pharmacy which can mix the cream for you. If you follow the link to Esowatch in this post you will find the recipe for this cream. This recipe is unfortunately in German, but the ingredients are:
      * 0.07g Vit­amin B12/Cyanocobalamin
      * 46 g Avo­cado Oil
      * 45.42 g Water
      * 8 g TEGO® Care PS (this is an emulsifier)
      * 0.26 g potassium sorbate
      * 0.25 g citric acid
      I did not try to have this recipe mixed, so I cannot take any responsibility for this recipe…..
      An other possibility for you might be to buy the cream online. This cream does not need a prescription (at least not in Germany) and it might be possible to have it shipped to you. Maybe try the UK site on the cream:
      Or any online pharmacy?
      Thats all I can come up with. I hope this helps.
      Good luck!

      • chloe says:

        thank you so much caroline that helps a lot!
        my friend from germany has used it an her skin looks amazing so im sure it will help 🙂

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